Marc Agnifilo is one of New York City’s most respected criminal defense attorneys, find out more about him and the high-profile cases that he takes up
Marc has over 30 years of legal practice experience, and has taken on over 200 trials, with many of them being high-profile and highly complex.
Marc Agnifilo, the attorney representing Luigi Mangione, recently said “it’s a great day” after a judge dropped terrorism charges against his client.
Mangione, 27 who has pleased guilty to all charges, is eligible for the death penalty if convicted at the federal level of fatally shooting Brian Thompson, CEO of UnitedHealthcare (UHC), outside a hotel in midtown Manhattan in December 2024.
Who is attorney Marc Agnifilo, lawyer of Luigi Mangione in the shooting case of UHC CEO Brian Thompson
“It’s a great day, it’s a big win and it’s the first of many” Marc Agnifilo
(It almost seems like he was going to say “special”at one point but then he switched his word choice 😊) pic.twitter.com/TWX2zghO0U
— Fair_trial_4_Luigi💚 (@Fairtrial4Luigi) September 17, 2025
"It's a great day. It's a big win and it's the first of many," defense attorney Mark Agnifilio said.
Agnifilio and his wife Karen ate part of the power legal team representing Luigi Mangione. pic.twitter.com/EL4JSygkHx
— Amber Speaks Up (@AmberWoods100) September 16, 2025
Over the years, Marc has represented clients in both U.S. courts and international jurisdictions, and presently defends major individuals and corporations.
Marc Agnifilo biography and age
Marc Agnifilo is a renowned and veteran trial lawyer with decades of courtroom experience. Ae 60 Marc is known for his composure and skill in high-pressure trials, and has earned respect over the years from both peers, judges, and clients alike his sharp strategy and persuasive advocacy.
The former Manhattan DA has tried more than 200 cases during his 30-year career.
Education
Marc Agnifilo studied philosophy and political science at Connecticut College before pursuing law. He earned his Juris Doctor with honors from Brooklyn Law School, where he co-chaired the Moot Court Honor Society and received the American Jurisprudence Award for Trial Advocacy.
Profession and career history
Marc Agnifilo started out his legal career in public service, working as an Assistant District Attorney in Manhattan. During his time there, he prosecuted violent crimes, corruption, and financial misconduct. Marc later became a supervisor at the U.S. Attorney’s Office for the District of New Jersey, where he oversaw complex cases involving racketeering, money laundering, and securities fraud. Marc eventually went no to co-found Agnifilo Intrater, which is a law firm dedicated to defending clients in complex criminal matters. His work spans across various federal and state courts all over the U.S. and extends to international jurisdictions as well, including Italy, Switzerland, Bulgaria, and Kyrgyzstan. Marc also conducts corporate internal investigations and represents clients in all kinds of grand jury proceedings.
Notable cases
Over the years, Marc Agnifilo has taken part in various notable cases and currently represents Sean “Diddy” Combs in a federal case involving s*x trafficking and racketeering, which is one of the most closely followed cases in the nation.
He has also represented pharma bro Martin Shkreli and former NXIUM cult leader Keith Raniere. Besides them, Marc has also successfully represented clients in international tax fraud disputes and high-stakes racketeering trials.
Wife and children
Marc Agnifilo is currently married to fellow lawyer Karen Friedman Agnifilo, who is the former Chief Assistant District Attorney of Manhattan. The couple share a strong partnership rooted in law and public service. They have three children together and reside in Manhattan, New York
Agnifilo’s daughter, Sofia Agnifilo is a paralegal.
Net worth
Marc Agnifilo has a net worth that runs in the millions although the exact figure isn’t known with most of his income coming from decades of legal practice, co-founding his law firm. He has also obtained substantial wealth from representing some of the most high-profile clients in the US and abroad.
Defense attorneys like Marc Agnifilo charge retainers of $1 million or more in complex federal cases.
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